WEB-based GEne SeT AnaLysis Toolkit
 
Translating gene lists into biological insights...
 


User data and parameters: User data: textAreaUpload.txt, Organism: hsapiens, Id Type: ensembl_gene_stable_id, Ref Set: entrezgene, Significance Level: Top10, Statistics Test: Hypergeometric, MTC: BH, Minimum: 2

The results for each enriched gene sets are listed in this table.
For each gene set, the first row lists database name, gene set name , and corresponding gene set ID.
The second row lists the following statistics:
Finally, genes in the pathway are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID, Ensembl Gene Stable ID, Gene symbol, and description. Ensembl Gene Stable ID and Entrez Gene ID are linked to the Ensembl and Entrez Gene databases, respectively.

Database:KEGG pathway       Name:Cell cycle       ID:04110
C=124; O=9; E=1.45; R=6.20; rawP=1.66e-05; adjP=0.0010
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000149311 NA ATM ataxia telangiectasia mutated 472 ENSG00000149311
2  ENSG00000175054 NA ATR ataxia telangiectasia and Rad3 related 545 ENSG00000175054
3  ENSG00000153107 NA ANAPC1 anaphase promoting complex subunit 1 64682 ENSG00000153107
4  ENSG00000108055 NA SMC3 structural maintenance of chromosomes 3 9126 ENSG00000108055
5  ENSG00000118007 NA STAG1 stromal antigen 1 10274 ENSG00000118007
6  ENSG00000253729 NA PRKDC protein kinase, DNA-activated, catalytic polypeptide 5591 ENSG00000253729
7  ENSG00000072501 NA SMC1A structural maintenance of chromosomes 1A 8243 ENSG00000072501
8  ENSG00000101972 NA STAG2 stromal antigen 2 10735 ENSG00000101972
9  ENSG00000002822 NA MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 8379 ENSG00000002822


Database:KEGG pathway       Name:Endometrial cancer       ID:05213
C=52; O=6; E=0.61; R=9.85; rawP=3.23e-05; adjP=0.0010
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000100485 NA SOS2 son of sevenless homolog 2 (Drosophila) 6655 ENSG00000100485
2  ENSG00000134982 NA APC adenomatous polyposis coli 324 ENSG00000134982
3  ENSG00000157764 NA BRAF v-raf murine sarcoma viral oncogene homolog B1 673 ENSG00000157764
4  ENSG00000100030 NA MAPK1 mitogen-activated protein kinase 1 5594 ENSG00000100030
5  ENSG00000051382 NA PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 5291 ENSG00000051382
6  ENSG00000121879 NA PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 5290 ENSG00000121879


Database:KEGG pathway       Name:Hepatitis C       ID:05160
C=134; O=9; E=1.57; R=5.74; rawP=3.09e-05; adjP=0.0010
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000100485 NA SOS2 son of sevenless homolog 2 (Drosophila) 6655 ENSG00000100485
2  ENSG00000033800 NA PIAS1 protein inhibitor of activated STAT, 1 8554 ENSG00000033800
3  ENSG00000157764 NA BRAF v-raf murine sarcoma viral oncogene homolog B1 673 ENSG00000157764
4  ENSG00000055332 NA EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 5610 ENSG00000055332
5  ENSG00000121879 NA PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 5290 ENSG00000121879
6  ENSG00000185386 NA MAPK11 mitogen-activated protein kinase 11 5600 ENSG00000185386
7  ENSG00000126456 NA IRF3 interferon regulatory factor 3 3661 ENSG00000126456
8  ENSG00000100030 NA MAPK1 mitogen-activated protein kinase 1 5594 ENSG00000100030
9  ENSG00000051382 NA PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 5291 ENSG00000051382


Database:KEGG pathway       Name:Regulation of actin cytoskeleton       ID:04810
C=213; O=11; E=2.49; R=4.41; rawP=4.82e-05; adjP=0.0011
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000100485 NA SOS2 son of sevenless homolog 2 (Drosophila) 6655 ENSG00000100485
2  ENSG00000157764 NA BRAF v-raf murine sarcoma viral oncogene homolog B1 673 ENSG00000157764
3  ENSG00000058272 NA PPP1R12A protein phosphatase 1, regulatory subunit 12A 4659 ENSG00000058272
4  ENSG00000121879 NA PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 5290 ENSG00000121879
5  ENSG00000134982 NA APC adenomatous polyposis coli 324 ENSG00000134982
6  ENSG00000196914 NA ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 23365 ENSG00000196914
7  ENSG00000138448 NA ITGAV integrin, alpha V 3685 ENSG00000138448
8  ENSG00000115020 NA PIKFYVE phosphoinositide kinase, FYVE finger containing 200576 ENSG00000115020
9  ENSG00000100030 NA MAPK1 mitogen-activated protein kinase 1 5594 ENSG00000100030
10  ENSG00000051382 NA PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 5291 ENSG00000051382
11  ENSG00000134318 NA ROCK2 Rho-associated, coiled-coil containing protein kinase 2 9475 ENSG00000134318


Database:KEGG pathway       Name:Progesterone-mediated oocyte maturation       ID:04914
C=86; O=7; E=1.01; R=6.95; rawP=7.01e-05; adjP=0.0013
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000185386 NA MAPK11 mitogen-activated protein kinase 11 5600 ENSG00000185386
2  ENSG00000153107 NA ANAPC1 anaphase promoting complex subunit 1 64682 ENSG00000153107
3  ENSG00000157764 NA BRAF v-raf murine sarcoma viral oncogene homolog B1 673 ENSG00000157764
4  ENSG00000100030 NA MAPK1 mitogen-activated protein kinase 1 5594 ENSG00000100030
5  ENSG00000051382 NA PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 5291 ENSG00000051382
6  ENSG00000121879 NA PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 5290 ENSG00000121879
7  ENSG00000002822 NA MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 8379 ENSG00000002822


Database:KEGG pathway       Name:Focal adhesion       ID:04510
C=200; O=10; E=2.34; R=4.27; rawP=0.0001; adjP=0.0015
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000100485 NA SOS2 son of sevenless homolog 2 (Drosophila) 6655 ENSG00000100485
2  ENSG00000157764 NA BRAF v-raf murine sarcoma viral oncogene homolog B1 673 ENSG00000157764
3  ENSG00000058272 NA PPP1R12A protein phosphatase 1, regulatory subunit 12A 4659 ENSG00000058272
4  ENSG00000100852 NA ARHGAP5 Rho GTPase activating protein 5 394 ENSG00000100852
5  ENSG00000121879 NA PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 5290 ENSG00000121879
6  ENSG00000138448 NA ITGAV integrin, alpha V 3685 ENSG00000138448
7  ENSG00000196569 NA LAMA2 laminin, alpha 2 3908 ENSG00000196569
8  ENSG00000100030 NA MAPK1 mitogen-activated protein kinase 1 5594 ENSG00000100030
9  ENSG00000134318 NA ROCK2 Rho-associated, coiled-coil containing protein kinase 2 9475 ENSG00000134318
10  ENSG00000051382 NA PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 5291 ENSG00000051382


Database:KEGG pathway       Name:RNA degradation       ID:03018
C=71; O=6; E=0.83; R=7.22; rawP=0.0002; adjP=0.0023
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000198677 NA TTC37 tetratricopeptide repeat domain 37 9652 ENSG00000198677
2  ENSG00000114127 NA XRN1 5'-3' exoribonuclease 1 54464 ENSG00000114127
3  ENSG00000138767 NA CNOT6L CCR4-NOT transcription complex, subunit 6-like 246175 ENSG00000138767
4  ENSG00000198791 NA CNOT7 CCR4-NOT transcription complex, subunit 7 29883 ENSG00000198791
5  ENSG00000125107 NA CNOT1 CCR4-NOT transcription complex, subunit 1 23019 ENSG00000125107
6  ENSG00000110367 NA DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 1656 ENSG00000110367


Database:KEGG pathway       Name:Lysine degradation       ID:00310
C=44; O=5; E=0.52; R=9.70; rawP=0.0002; adjP=0.0023
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000147548 NA WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1 54904 ENSG00000147548
2  ENSG00000116539 NA ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 55870 ENSG00000116539
3  ENSG00000145391 NA SETD7 SET domain containing (lysine methyltransferase) 7 80854 ENSG00000145391
4  ENSG00000008311 NA AASS aminoadipate-semialdehyde synthase 10157 ENSG00000008311
5  ENSG00000181555 NA SETD2 SET domain containing 2 29072 ENSG00000181555


Database:KEGG pathway       Name:Non-small cell lung cancer       ID:05223
C=54; O=5; E=0.63; R=7.91; rawP=0.0004; adjP=0.0040
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000100485 NA SOS2 son of sevenless homolog 2 (Drosophila) 6655 ENSG00000100485
2  ENSG00000157764 NA BRAF v-raf murine sarcoma viral oncogene homolog B1 673 ENSG00000157764
3  ENSG00000100030 NA MAPK1 mitogen-activated protein kinase 1 5594 ENSG00000100030
4  ENSG00000051382 NA PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 5291 ENSG00000051382
5  ENSG00000121879 NA PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 5290 ENSG00000121879


Database:KEGG pathway       Name:Acute myeloid leukemia       ID:05221
C=57; O=5; E=0.67; R=7.49; rawP=0.0005; adjP=0.0041
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000100485 NA SOS2 son of sevenless homolog 2 (Drosophila) 6655 ENSG00000100485
2  ENSG00000157764 NA BRAF v-raf murine sarcoma viral oncogene homolog B1 673 ENSG00000157764
3  ENSG00000100030 NA MAPK1 mitogen-activated protein kinase 1 5594 ENSG00000100030
4  ENSG00000051382 NA PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 5291 ENSG00000051382
5  ENSG00000121879 NA PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 5290 ENSG00000121879




WebGestalt is currently developed and maintained by Jing Wang and Bing Zhang at the Zhang Lab. Other people who have made significant contribution to the project include Dexter Duncan, Stefan Kirov, Zhiao Shi, and Jay Snoddy.

Funding credits: NIH/NIAAA (U01 AA016662, U01 AA013512); NIH/NIDA (P01 DA015027); NIH/NIMH (P50 MH078028, P50 MH096972); NIH/NCI (U24 CA159988); NIH/NIGMS (R01 GM088822).